Psych follows the story of Shawn Spencer who uses his cunning perception to solve crimes, under the guise of a psychic. Although set in Santa Barbara, Psych was primarily filmed in Vancouver, Canada. Lots of locations found thanks to this forum post.
Zoom to: Vancouver, BC,
Industrial area where Mr. Yin leads the team and captures Juliet in episode #416 "Mr. Yin Presents".
Warehouse where Mr. Yin draws Mary and later the team in episode #416 "Mr. Yin Presents". (I'm fairly certain this is here)
Establishing shot of the police station used throughout the series.
Location where Shawn and Juliet talk at the end of episode #401 "Extradition: British Columbia".
Abandoned mental hospital that appears in episode #115 "Scare Sherry: Bianca's Toast".
Resort where Shawn take Juliet for their romantic vacation in episode #609 "Neil Simon's Lovers Retreat".
Donut store where Lassiter shot the giant donut while in a drugged haze in episode #602 "Last Night Gus".
Building where Father Peter Westley has his offices in episode #404 "The Devil's in the Details and in the Upstairs Bedroom".
Santa's village where Shawn and Gus go to talk to the con artist santa in episode #309 "Christmas Joy".
Sorority house where the "paranormal" events occur in episode #115 "Scary Sherry: Bianca's Toast".
Restaurant where Shawn and Gus go to investigate the cheese-infused twice-battered fries in episode #314 "Truer Lies".
Where Shawn and Gus go to track down Colin and then attempt to comendeer a vehicle in episode #601 "Shawn Rescues Darth Vader".
Police station entrance used in the pilot and when Lassiter's car is stolen in episode #204 "Zero to Murder in Sixty Seconds"
Camp where the pool scene from episode #315 "Tuesday the 17th" take place. This pool has since been removed.
Street (just outside the entrance to the park) where Juliet and Lassiter pull over the wrong car in episode #513 "We'd Like to Thank the Academy".
Area where Shawn and Gus go through the SBPD obstacle course & shooting gallery in episode #513 "We'd Like to Thank the Academy".
Diner where Shawn & Gus talk with Mary at the start of episode #416 "Mr. Yin Presents".
Football stadium at the end of episode #313 "Any Given Friday Night at 10PM, 9PM Central".
Bank where the robbery occurs in episode #308 "Gus Walks Into a Bank".
Psychiatric facility where Shawn and Gus go undercover to reveal that Bernie Bethel is faking his mental illness in episode #606 "Shawn Interrupted".
The hotel where Shawn and Gus stay in episode #510 "Extradition II: The Actual Extradition Part".
Street where the events in the street near the end of episode #514 "The Polarizing Express" take place.
Bank where Shawn & Gus talk to Gillian & Clive in episode #504 "Chivalry Is Not Dead…But Someone Is".
Train station where Juliet leaves from in episode #412 "A Very Juliet Episode".
Building from which girl jumps in episode #404 "The Devil's in the Details and in the Upstairs Bedroom".
Theatre where the first murder of the episode takes place in episode #504 "Chivalry Is Not Dead…But Someone Is".
Beach where Juliet and Lassiter talk about the case in episode #105 "9 Lives". Also the beach that young Shawn runs down in his cape at the start of episode #108 "Shawn vs. the Red Phantom" and where nowadays Shawn talks with Talia later in that episode. Where the dead surfer is found in episode #502 "Feet Don't Kill Me Now".
House where a UFO supposedly abducted Toby Shore in episode #503 "Not Even Close…Encounters".
Studio where the spanish soap opera is filmed in episode #213 "Lights, Camera… Homicidio".
Ridge where the Shawn and Gus join the S&R team at the start of episode #402 "He Dead".
Coffee shop where Shawn and Gus go to begin their investigation at the beginning of episode #109 "Forget Me Not". Also where Shaun and Gus meet up with Brandon for their fake date in episode #114 "Poker? I Barely Know Her". It is also where an infection occurs in episode #413 "Death is in the Air".
Restaurant where Dutch the Clutch jumps off the balcony from in episode #303 "Daredevils!". Also where the Mr. Yang clue is left near the beginning of episode #316 "An Evening with Mr. Yang".
Dock where Henry keeps his boat in episode #310 "Six Feet Under the Sea". Also the dock where Lassiter & Juliet go to try and get a boat to hunt the shark and where Shawn & Gus leave with the fisherman in episode #415 "The Head, the Tail, the Whole Damn Episode".
Location where Shawn and Juliet have their talk followed by make out session at the end of episode #510 "Extradition II: The Actual Extradition Part".
First silk factory in central California that Lassiter chases Jerry by near the end of episode #609 "Neil Simon's Lovers Retreat".
Motel where Lassiter and Juliet stake out some bank robbers in episode #104 "Woman Seeking Dead Husband - Smokers Okay, No Pets".
Street where Shawn & Gus drive up and talk to Juliet & Lassiter in episode #107 "Who Ya Gonna Call?".
House where Derek & Melanie Ford live in episode #305 "Disco Didn't Die. It Was Murdered!".
Lassiter's house where his surprise party is held in episode #114 "Poker? I Barely Know Her".
Location where Shawn and Gus first see The Mantis in episode #604 "The Amazing Psych-Man & Tap Man, Issue No. 2".
Grocery store with the secret betting parlor in the back in episode #513 "We'd Like to Thank the Academy".
Restaurant where Lassiter and his partner are eating lunch in episode #101 (the pilot).
Pier where Westwood hides the "body" and is observed by Shawn and Gus in episode #307 "Talk Derby to Me".
Exterior of the RCMP station in episodes #401 "Extradition: British Columbia" & #510 "Extradition II: The Actual Extradition Part".
House where Shawn & Gus go to talk to the mother of the missing teen in episode #108 "Shawn vs. the Red Phantom".
Restaurant Shawn, Gus, & Uncle Burton leave in episode #206 "Meat Is Murder, But Murder Is Also Murder". Also where Shawn & Gus talk to a client at the beginning of episode #207 "If You're So Smart, Then Why Are You Dead?".
Street vendor where Shawn and Gus get churros in episode #108 "Shawn vs. the Red Phantom".
Restaurant where the police softball team eat after the game in episode #405 "Shawn Has the Yips". Also where the party for the retired police officer occurs in episode #602 "Last Night Gus".
The Home Depot store where the team investigates the counterfeited money in episode #203 "Psy vs. Psy".
Baseball stadium where the bulk of the action occurs in episode #605 "Dead Man's Curveball".
Store where Henry goes to get the pocket watch for Shawn in episode #106 "Weekend Warriors".
Street where Shawn and Gus talk before Shawn leaves on his romantic getaway with Juliet in episode #609 "Neil Simon's Lovers Retreat".
Residence where Shawn steals the Darth Vader and then finds the dead body in episode #601 "Shawn Rescues Darth Vader".
Restaurant where the team arrested Eugenia at the end of episode #504 "Chivalry Is Not Dead…But Someone Is". The location of the car crash that delays the team is just down the hill from here.
Hospital where Tom Lieber is kidnapped from in episode #314 "Truer Lies".
House where Shawn & Gus begin there first investigation in episode #101 (the pilot).
Gus and Shawn actually visit the Whistler Backcomb Ski Park in episode #401 "Extradition: British Columbia".
Tennis courts where Shawn & Gus talk with a young tennis player about this missing tennis star in episode #113 "Game, Set… Muuurder?".
Burger place where Dwyer has chained herself in protest in episode #206 "Meat Is Murder, But Murder Is Also Murder".
Pier where Shawn confronts Despereaux at the end of episode #401 "Extradition: British Columbia".
Spot where Clive and Barbie set up their ambush and rob people on the road in episode #609 "Neil Simons's Lover's Retreat".
Pawn shop where Shawn, Gus, & Henry change in to 70s clothes in episode #305 "Disco Didn't Die, It Was Murdered!".
Where Henry was storing the shark after he caught it in episode #415 "The Head, the Tail, the Whole Damn Episode".
Climbing gym where Shawn & Gus go climbing with Ruby's group in episode #411 "Thrill Seekers and Hell Raisers".
Observatory at the Santa Barbara Space Center in episode #110 "From the Earth to Starbucks".
Car dealership where Brandon Peterson goes with Shawn and Gus to meet his father in episode #114 "Poker? I Barely Know Her".
Biker bar where Shawn and Gus go in order to locate Dwayne Tancana in episode #209 "Bounty Hunters!".
Disco club where Shawn, Gus, and Henry go in episode #305 "Disco Didn't Die. It Was Murdered!".
Cafe where Shawn & Juliet talk in episode #103 "Speak Now or Forever Hold Your Piece". Filmed in the Tramonto restaurant overlooking the marina.
Location of arrest at the end of episode #204 "Zero to Murder in Sixty Seconds".
Where Juliet talks to Alice Bundy in episode #115 "Scary Sherry: Bianca's Toast". Also used as an establishing shot in episode #415 "The Head, the Tail, the Whole Damn Episode".
Park where Juliet get fake married to Rajesh Singh as part of a sting operation in episode #406 "Bollywood Homicide".
Bus station where the team stops the finally bioterrorism attack in episode #413 "Death Is in the Air".
Where the bell tower used to stand that the team locates during the treasure hunt in episode #304 "The Greatest Adventure in the History of Basic Cable".
Road approaching the spot where Clive and Barbie set up their trap in episode #609 "Neil Simons's Lover's Retreat".
Dentist's office where Shawn and Gus go snooping in episode #106 "Weekend Warriors".
Theatre where the show within a show "American Duos" takes place in episode #201 "American Duos".
Street where the race takes place in episode #505 "Shawn and Gus in Drag (Racing)". The race starts out heading eastbound and ends going westbound near the same spot.
Parking lot where Shawn and Gus finally manage to stop their truck at the end of the race in episode #505 "Shawn and Gus in Drag (Racing)".
Interior of the school in episode #302 "Murder?… Anyone?… Anyone?… Bueller?".
Art gallery where the final theft occurs in episode #401 "Extradition: British Columbia".
Coffee shop where Shawn, Gus, & Lassiter look at the stuff in the back of Henry's truck in episode #113 "Game, Set… Muuurder?". Also where Shawn fake proposes to Juliet in episode #208 "Rob-a-Bye Baby".
Clinic on Gus's route where Shawn finds him to talk about the case in episode #101 (the pilot).
The pharmaceutical company where Gus works as it appears in episode #301 "Ghosts".
Parking lot where Shawn meets Uncle Burton for the first time in episode #206 "Meat Is Murder, But Murder Is Also Murder". Also where the destroyed Blueberry is parked in episode #602 "Last Night Gus".
Gardens where girl is kidnapped at the start of episode #501 "Romeo and Juliet and Juliet".
Archaeology department where the murder victim worked in episode #202 "65 Million Years Off".
Lab where Dr. Richard Colbert is found dead in episode #305 "Disco Didn't Die. It Was Murdered!".
Where Shawn and Gus talk with the arson inspector in episode #312 "Earth, Wind and… Wait for it".
Shawn, Gus, and Nick spot the suspect here and begin chasing him through the streets in episode #513 "We'd Like to Thank the Academy".
Bus stop where Lassiter and Juliet get off the bus upon first arriving in Canada in episode #401 "Extradition: British Columbia".
Park where Shawn and Gus creepily investigate nannies before getting taken away by McNab in episode #208 "Rob-a-Bye Baby".
Parking lot where the team meets before going to see the polar bear crime scene in episode #515 "Dead Bear Walking".
Location of the first Pierre Despereaux crime scene investigated in episode #401 "Extradition: British Columbia".
Location of the sting operation at the start of episode #513 "We'd Like to Thank the Academy".
The doctor's office where Shawn and Gus go to solve the case in episode #214 "Dis-Lodged".
House where Shawn, Gus, and Nick track the suspects and find a recently attacked Dickie in episode #513 "We'd Like to Thank the Academy".
Dormitory at Santa Barbara Institute of Technology in episode #513 "We'd Like to Thank the Academy" where the criminals are tracked too.
The safety inspector's house that Shawn & Gus search in episode #306 "There Might Be Blood".
House of the dead hitting coach that Shawn and Gus investigate at the beginning of episode #605 "Dead Man's Curveball".
Bridge that Lassiter chases the Jerry over near the end of episode #609 "Neil Simon's Lovers Retreat".
Cafe where Shawn speaks with the hippie in episode #515 "Dead Bear Walking".
Store where Juliet & Lassiter search Regina Cain's PO box in episode #107 "Who Ya Gonna Call?".
Interior of the football training camp in episode #313 "Any Given Friday Night at 10PM, 9PM Central".
Road where Shawn escapes during the car chase at the end of episode #409 "Shawn Takes a Shot in the Dark". Also where Tommy drives the Laborghini towards the police road block in episode #505 "Shawn and Gus in Drag (Racing)".
Location of the polar bear pit in episode #515 "Dead Bear Walking".
Location of the science fiction convention in episode #108 "Shawn vs. the Red Phantom".
Nightclub where Shawn and Gus attend the Ciao! launch party in episode #215 "Black and Tan: A Crime of Fashion".
Street where Shawn, Gus, and Ruby talk at the beginning of episode #411 "Thrill Seekers and Hell Raisers".
Farm where Shawn brings the Lamborghini to free Gus in episode #505 "Shawn and Gus in Drag (Racing)".
Location of Brandon Peterson's former apartment in episode #114 "Poker? I Barely Know Her".
Apartment building where McNab is nearly blown up with a mail bomb in episode #405 "Shawn Has the Yips".
Dance studio where Gus takes tap-dance lessons and teaches them to Lassiter in episode #502 "Feet Don't Kill Me Now".
Field where Shawn overcomes his mental block at the end of episode #405 "Shawn Has the Yips".
Dock where Lassiter & Juliet get on the police boat and leave Shawn & Gus behind in episode #415 "The Head, the Tail, the Whole Damn Episode".
Alley where Leonard climbs the ladder to his apartment at the start of episode #407 "High Top Fade Out".
Location of the football training camp in episode #313 "Any Given Friday Night at 10PM, 9PM Central".
Apartment building containing the crime scene at the beginning of episode #105 "9 Lives".
Tanning Salon where the victims were tanning in episode #111 "He Loves Me, He Loves Me Not, He Loves Me, Oops He's Dead".
Apartment where Despereaux hangs a man from the window in episode #510 "Extradition II: The Actual Extradition Part".
Movie theater where Shawn pretends to see "The Little Mermaid" in the intro of episode #416 "Mr. Yin Presents".
Fire station where Shawn and Gus go to investigate the fires in episode #312 "Earth, Wind, and… Wait for It".
Motel where Shawn & Gus talk to Ben and then he is arrested by Juliet & Lassiter in episode #502 "Feet Don't Kill Me Now".
Pier where Shawn & Gus are not allowed to board the Coast Guard pier and where they meet the oil baron in episode #306 "There Might Be Blood".
Diner where Shawn & Gus track Dwayne to and then first see the bounty hunter in action in episode #209 "Bounty Hunters!".
Coffee shop where Shawn wins his free drink by answering a trivia question every day in episode #508 "Shawn 2.0".
Law firm that Shawn and Gus follow Toby Shore from, then chase him while wearing silly costumes in episode #503 "Not Even Close…Encounters".
Alley where the stolen Lamborghini is stolen from in episode #505 "Shawn and Gus in Drag (Racing)".
Where Lassiter loses the Lamborghini he was chasing in episode #505 "Shawn and Gus in Drag (Racing)".
Location of the crashed Lamborghini with the dead body in it in episode #505 "Shawn and Gus in Drag (Racing)".
Where the car is pulled from the water at the start of episode #502 "Feet Don't Kill Me Now".
Shawn and Gus find Peters and Boone intimidating a witness and then walk back to their car in episode #506 "Viagra Falls".
Location where Nicole witnessed the murder and is almost run over later in episode #608 "The Tao of Gus".
Where Shawn and Henry locate the murder victim on a traffic camera in episode #608 "The Tao of Gus".
Hanger where Shawn forces Gus to take flying lessons while he snoops around in episode #402 "He Dead".
Shawn and Gus are driven into the base by Ewan O'Hara in episode #410 "You Can't Handle This Episode".
Exterior of For Nicholas Army base in episode #410 "You Can't Handle This Episode".