The Royal Tobacco Factory began construction in 1728 and took 30 years to complete, beginning production in 1758 to concentrate all Spanish tobacco processing in one large structure, one of the largest buildings in Spain at the time, second only to El Escorial. In 1950 tobacco production was moved across the river and the building was transformed by architects Alberto Balbontín de Orta, Delgado Roig, and Toro Buiza to become the headquarters for the University of Seville.
The team sneaks through the Vatican and split up to accomplish their own tasks in episode 1x09 “2 Corinthians 10:4”. Pope Duretti dons his a new outfit to fit his new role. Later, after escaping the catacombs, the nuns face off against Adriel and realize they've been betrayed in episode 1x10 “Revelation 2:10”.