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Wade (Dan Aykroyd) and Glenn (John Lithgow) house. Exterior establishing shot is 380 S. San Rafael, unknown if the interiors are too.
This estate is used for the bridal shower scene.
From episode 8x15 "Tinker, Tailor, Liar, Thief".
From episode 4x02 "Authorized Personnel Only: Part 2".
Source: Janet Burke