A Tudor Revival mansion building for whiskey baron Edward Tulk in 1915. Now a privately owned residence and a Vancouver heritage building.
Shawn goes to the sorority house at Juliet's request to search for signs of a haunting in episode 1x15 "Scary Sherry: Bianca's Toast".
Source: Psych Forums
Jack and Maybourne break into the safe house and find out what the captured Goa'uld knows in episode 5x14 "48 Hours". Kinsey is taken to a N.I.D. safe house in episode 8x14 "Full Alert".
Russian soldiers capture Daniel an interrogate him about his interest in General Miroslav Kiselev in episode 8x14 "Full Alert".
Source: James Steuart
The team goes to stop a soul who thought she was a vampire in episode #205 "I Want My Baby Back".