Trajectory uses her speed to bring down a bridge and Barry has to work to save the people on it in episode 2x16 "Trajectory".
Oliver, Felicity, and Diggle drive into town during the fight over the city in episode 3x07 "Draw Back Your Bow".
Dinah stops Black Siren and her team while they are driving across the city in episode 6x01 "Fallout".
Kara and Clark arrive to stop a jumper only to find Metallo waiting for them in episode 2x02 "The Last Children of Krypton".
Scully works her way through traffic to Mulder and Miller with the cure in episode 10x06 "My Struggle II". Mulder is heading down the highway when he notices someone following him and speeds up to evade pursuit in episode 11x01 "My Struggle III".
Deadpool attacks Francis's people on the highway but Francis escapes when Colossus and Negasonic Teenage Warhead arrive.
Deadpool sits on a high overpass waiting for Francis's convoy to pass underneath.