Enchanted
Times Square
Giselle and several other people from the other side arrive through a manhole in Times Square.
Times Square is an incredible popular tourist destination at the heart of Manhattan's Broadway Theater District. The north half of the square is also known as Father Duffy Square, named in 1937 after U.S. Army Chaplain Francis P. Duffy who was the most highly decorated cleric in the history of the Army for his service during WWI. The square contains the distinctive red TKTS booth with tiered seating and a statue of the father of American musical comedy, George M. Cohan. The south side of Times Square continues past 45th Street.
Giselle and several other people from the other side arrive through a manhole in Times Square.
Amy and the Doctor head back to the TARDIS after learning of Rory's fate in episode 7x05 “The Angels Take Manhattan”.
Source: The Doctor Who Locations Guide
Liza is hiding out away from the mayhem when Caitlin finds her and assumes she is working as a regular costumed character in episode 2x11 “Secrets & Liza”.
Finch hacks DoD and gains information on the facility Reese and Mark Snow are breaking into in episode 2x13 “Dead Reckoning”. Reese stands in the middle of Times Square to test the rebuilt Machine's ability to track him in episode 5x02 “SNAFU”.
Clint tells Kate about his hearing and and they spy some people dressed up as superheroes posing for photos in episode 1x02 “Hide and Seek”. Clint walks through Times Square and calls up Laura in episode 1x05 “Ronin”.
Steve runs into the center of Times Square and is soon surrounded by S.H.I.E.L.D. agents and greeted by Nick Fury.
Source: IMDb