The Flash
Central City Square
The Trickster hands out bombs to children while dressed as Santa and then the Flash arrives to fight Weather Wizard in episode 2x09 “Running to Stand Still”.
A public plaza in the center of downtown Vancouver connecting the Vancouver Art Gallery and the Provincial Law Courts. Underwent a multi-million dollar renovation in 2009 for the Olympics. Also holds a satellite campus of the University of British Columbia.
The Trickster hands out bombs to children while dressed as Santa and then the Flash arrives to fight Weather Wizard in episode 2x09 “Running to Stand Still”.
Scully meets with her old colleague Monica Reyes and learns about the Cigarette Smoking Man's plan in episode 10x06 “My Struggle II”.
Michelle Generoo approaches Mulder & Scully and gives them the leaked x-rays in episode 1x09 “Space”.
The observers talk about September's transgressions at the start of episode #414 "The End of All Things".
The team watches Savage give a speech to his troops in episode 1x13 “Leviathan”.
Source: YVRShoots
Clark and Kara fall to the city and fight in a fountain in the middle of downtown in episode 2x22 “Nevertheless, She Persisted”.
A man playing the guitar on the street notices the Tomorrowland pin in his case.
Lucy gives Flynn the information he needs to save his wife but Flynn is arrested by Denise Christopher and her agents before he can head back in episode 1x16 “The Red Scare”.